This guide shows dental and oral and maxillofacial surgeons how to diagnose, prevent, and treat drug-induced osteonecrosis of the jaws. It explains how specific medications can cause this condition; the prevention and management of it in patients treated for osteopenia, osteoporosis, and cancer; antibiotic protocols that can control secondary infection; and a staging system for disease assessment and treatment planning. Sample cases are provided throughout, with patient evaluation information, a suggested course of action, and rationales.